DP2-E2F4 Complex Regulates MiRNA Expression (P19674)

Target Name: DP2-E2F4 complex

NCBI ID: P19674

Other Name(s): None

DP2-E2F4 Complex Regulates MiRNA Expression

The DP2-E2F4 complex is a protein complex that is expressed in various tissues of the body, including the brain. It is composed of two subunits, DP2 and E2F4, which are known to play important roles in cell signaling pathways.

The DP2 subunit is a 24 kDa protein that contains a nucleotide-binding oligomerization domain (NBD) and a leucine-rich repeat (LRR) domain. The NBD is a common structural motif that is involved in protein-protein interactions, while the LRR domain is a protein-DNA interaction domain that is known to play a role in transcriptional regulation.

The E2F4 subunit is a 21 kDa protein that contains an E2F1 domain and a N-terminal region that is rich in acidic amino acids. The E2F1 domain is a known structural domain that is involved in protein-protein interactions and is similar to the E2F2 domain , which is a conserved protein-protein interaction domain that is found in various proteins. The N-terminal region of the E2F4 subunit contains several acidic amino acids that are important for protein stability and may contribute to the protein's localization to the nucleus.

The DP2-E2F4 complex is involved in various cellular processes, including cell signaling pathways, DNA replication, and chromatin remodeling. One of the most well-studied functions of the DP2-E2F4 complex is its role in the regulation of microRNA (miRNA) expression .miRNA is a type of non-coding RNA molecules that regulate gene expression in cells. In humans, miRNAs play a role in regulating gene expression and controlling physiological processes such as cell cycle, tissue development and immune response.

The regulation of miRNA expression involves a variety of complex biochemical processes, including RNA-binding protein (RBP)-mediated binding, RNA-induced RNA binding, and RNA degradation. The DP2-E2F4 complex is one of the key players in regulating these biochemical processes.

Studies have shown that the DP2-E2F4 complex can inhibit the expression of miRNA molecules by binding to them. This inhibitory effect is through the binding of DP2 and E2F4 subunits to miRNA molecules, resulting in the inability of the miRNA molecules to bind to the corresponding RBPs and thus the inability to be transcribed into mature miRNA molecules. In addition, the DP2-E2F4 complex can further increase the binding ability to miRNA and enhance its inhibitory effect by binding to the companion RNA of miRNA (cis-ePPT).

In addition, the DP2-E2F4 complex is also involved in many biological processes related to cell cycle and apoptosis. For example, in mitosis, the DP2-E2F4 complex binds to histones (histones are proteins mainly responsible for storing and replicating DNA), promoting the assembly and separation of histones, thereby participating in the maintenance of chromosome structure and function. During apoptosis, the DP2-E2F4 complex binds to lysosomes (lysosomes are membrane structures containing hydrolases in cells), promoting lysosomes to release harmful substances in cells, such as DNA and protein fragments. , thereby participating in the programmed cell death process of apoptosis.

In addition, the DP2-E2F4 complex is also connected to many important biological processes, such as cell proliferation, differentiation, and tumor formation. In tumorigenesis, the DP2-E2F4 complex can participate in the growth and invasion of tumor cells in various ways. For example, it can control the growth of tumor cells by inhibiting miRNA expression and can also promote the proliferation of tumor cells by promoting G1 phase progression in the cell cycle.

DP2-E2F4 complex is a protein complex with important functions in cell biology. By binding to miRNA molecules, it can regulate miRNA expression, thereby affecting biological processes such as cell cycle, differentiation, and tumor formation. These functions make the DP2-E2F4 complex a potential drug target (or biomarker)

Protein Name: DP2-E2F4 Complex

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